IdentificationTaxonomyBiological PropertiesPhysical PropertiesToxicity ProfileSpectraConcentrationsLinksReferencesGene RegulationXML


You are watching: Hydrazine is an inorganic compound with the formula n2h4

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SynonymsSynonymAmerzineCatalyzed hydrazineDiamideDiamineDiazaneHDZHydrazinHydrazine (anhydrous)Hydrazine baseHydrazine solutionHydrazinesLevoxineNitrogen hydrideOxytreat 35Scav-ox IIZeroxChemical FormulaH4N2Average molecule Mass32.045 g/molMonoisotopic Mass32.037 g/molCAS registry Number302-01-2IUPAC NamehydrazineTraditional NamehydrazineSMILESNNInChI IdentifierInChI=1S/H4N2/c1-2/h1-2H2InChI KeyInChIKey=OAKJQQAXSVQMHS-UHFFFAOYSA-NChemical TaxonomyDescription belongs to the class of not natural compounds recognized as homogeneous various other non-metal compounds. These are inorganic non-metallic compound in i beg your pardon the biggest atom belongs to the class of "other non-metals".KingdomInorganic link Super ClassHomogeneous non-metal compounds ClassHomogeneous other non-metal compounds Sub ClassNot AvailableDirect ParentHomogeneous other non-metal link Alternative ParentsSubstituentsHomogeneous various other non metalHydrazine derivativeMolecular FrameworkNot AvailableExternal DescriptorsBiological PropertiesStatusDetected and Not QuantifiedOriginExogenousCellular LocationsCytoplasmExtracellularBiofluid LocationsNot AvailableTissue LocationsKidneyLiverPathwaysNot AvailableApplicationsNot AvailableBiological RolesChemical RolesPhysical PropertiesStateLiquidAppearanceColorless liquid.Experimental PropertiesPropertyValueMelting Point
2°C
Boiling PointNot Available
Solubility1000 mg/mL
LogP-2.07
Predicted PropertiesPropertyValueSourcelogP
-1ChemAxon
pKa (Strongest Basic)5.4ChemAxon
Physiological Charge0ChemAxon
Hydrogen agree Count2ChemAxon
Hydrogen Donor Count2ChemAxon
Polar surface ar Area52.04 ŲChemAxon
Rotatable bond Count0ChemAxon
Refractivity10.57 m³·mol⁻¹ChemAxon
Polarizability3.25 ųChemAxon
Number the Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber"s RuleYesChemAxon
MDDR-like RuleYesChemAxon
SpectraSpectraSpectrum TypeDescriptionSplash KeyViewPredicted GC-MS
Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-001i-9000000000-7e6c9f4fe38a72218c48JSpectraViewer
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, PositiveNot AvailableJSpectraViewer
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, PositiveNot AvailableJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-001i-9000000000-401f7c59e214d2145c6bJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-001i-9000000000-401f7c59e214d2145c6bJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-001i-9000000000-401f7c59e214d2145c6bJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-001i-9000000000-d34c4424b02bfa4ea545JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-001i-9000000000-d34c4424b02bfa4ea545JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-001i-9000000000-d34c4424b02bfa4ea545JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-001i-9000000000-45c21befbfc7d627145cJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-001i-9000000000-45c21befbfc7d627145cJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-001i-9000000000-45c21befbfc7d627145cJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-001i-9000000000-b155ef0ff565a5a1d372JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-001i-9000000000-b155ef0ff565a5a1d372JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-001i-9000000000-b155ef0ff565a5a1d372JSpectraViewer
Toxicity ProfileRoute of ExposureOral (5); inhalation (5) ; dermal (5) Mechanism the ToxicityAt the very least two instrument of action have been observed. One entails the straight binding that those hydrazines with a cost-free amino group (hydrazine and also 1,1-dimethylhydrazine) to crucial cellular molecules. Hydrazine reacts with alpha-keto mountain such together vitamin B6 to form hydrazoines compounds. Through binding come keto acids and also forming hydrazones, hydrazine inhibits oxygen intake with mitochondrial substrates in vitro. A second mechanism involves the generation of reactive types such as cost-free radical intermediates or methyldiazonium ions as a an outcome of metabolism. (6)MetabolismHydrazines are likely to be much more rapidly absorbed into the blood after ingestion or exposure to the skin 보다 after inhalation. As soon as in the blood, they space probably brought to all the organization of the body. Soon after exposure, the levels of hydrazines in the tissues fall since they room metabolised in several products such together acetyl-, diacetylhydrazine, pyruvate hydrazone, urea, and also acyclic compound (1,4,5,6-tetrahydro-6-oxo-3-pyridazine carboxylic acid). However, these metabolites interacts with some essential proteins and also might be harmful come the body. Part studies showed that metabolites and also unchanged hydrazine leaving the human body within one day. Small amounts can likewise be found in the expired air. (6, 1)Toxicity ValuesLD50: 60 mg/kg (Oral, Rat)LD50: 91 mg/kg (Dermal, Rabbit)LC50: 570 ppm end 4 hrs (Inhalation, Rat) (7)Lethal DoseNot AvailableCarcinogenicity (IARC Classification)2B, maybe carcinogenic to humans. (3)Uses/SourcesHydrazine is mostly used as a foaming agent in prepare polymer foams, but far-reaching applications likewise include its provides as a precursor come polymerization catalysts and also pharmaceuticals. Additionally, hydrazine is supplied in various rocket fuels and also to prepare the gas precursors supplied in wait bags. Exposure may take place from breath contaminated air in or near a facility that makes, processes, or provides hydrazines, eating fish contaminated v hydrazines, drink or swim in water that has been contaminated v hydrazines, or poignant soil contaminated v hydrazines, together as near some armed forces bases or hazardous rubbish sites. Breathing cigarette smoke indirect or utilizing tobacco commodities may disclose to small amounts that hydrazine or 1,1-dimethylhydrazine. (6) Minimum risk LevelIntermediate Inhalation: 0.004 ppm (2)Health EffectsBreathing hydrazines for quick periods may cause coughing and irritation the the throat and also lungs, convulsions, tremors, or seizures. Breath hydrazines for long periods may cause liver and also kidney damage, and also serious effects on reproductive organs. Eating or drinking tiny amounts that hydrazines may reason nausea, vomiting, uncontrolled shaking, inflammation of the nerves, drowsiness, or coma. (6)SymptomsHydrazine may reason corrosive burning sensations, confusion, convulsions, abdominal muscle cramps, headache, unconsciousness, vomiting, weakness, shortness of breath, or sick throat and also cough, relying on the path of exposure. (5)TreatmentInduced emesis, gastric lavage, use of saline cathartics, or activated charcoal are commonly used come decrease the gastrointestinal absorption of hydrazines. In general, this treatments room most reliable when offered within a few hours after dental exposure. Following dermal or ocular exposures to hydrazines, all contaminated garments should it is in removed, and also contacted skin should be washed immediately with soap and also water. Eye that have come in call with hydrazines should be flushed with copious quantities of water. Call lenses have to be removed before flushing v water. (6)Normal ConcentrationsNot AvailableAbnormal ConcentrationsNot AvailableExternal LinksDrugBank IDNot AvailableHMDB IDHMDB12973 PubChem link ID9321 ChEMBL IDCHEMBL1237174 ChemSpider ID8960 KEGG IDC05361 UniProt IDNot AvailableOMIM IDChEBI ID15571 BioCyc ID4-HYDROXYMETHYLPHENYLHYDRAZINE CTD IDC029424 Stitch IDHydrazine PDB IDNot AvailableACToR ID713Wikipedia Linkhydrazine ReferencesSynthesis ReferenceNot AvailableMSDSLinkGeneral ReferencesGene RegulationUp-Regulated GenesGeneGene SymbolGene IDInteractionChromosomeDetails
Down-Regulated GenesNot Available