Medically the review by Darren Hein, PharmD — written by college of Illinois — to update on September 2, 2018


Mucinex and also Nyquil Cold & Flu room two common, over-the-counter remedies girlfriend can discover on her pharmacist’s shelf. Compare the symptoms the each medicine treats as well as their side effects, interactions, and warnings to see if one is a far better option because that you.

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The key differences between these drugs are their active ingredients and also how those work to treat her symptoms.

Mucinex treats chest congestion. The main active ingredient is one expectorant called guaifenesin. It functions by thinning the consistency of mucus in her air passages. This i got loose up rubber in your chest therefore you can cough that up and also out.

NyQuil temporarily treats typical cold and flu symptoms such as fever, cough, nasal congestion, young aches and pains, headache, and also runny nose and sneezing. The energetic ingredients room acetaminophen, dextromethorphan, and doxylamine. This ingredients each occupational a tiny differently.

For example, acetaminophen is a pains reliever and also fever reducer. It alters the means your human body senses pain and regulates temperature. Dextromethorphan suppresses the signals in your brain that cause your sneeze reflex. Doxylamine, ~ above the other hand, block a substance in her body dubbed histamine. This substance causes allergy symptom such as itchy, watery eyes, runny nose, and also itchy nose or throat. Together, this ingredients administer the relief girlfriend can obtain from NyQuil.

The complying with table summarizes the differences in between Mucinex and also NyQuil in ~ a glance.

Active ingredient(s)guaifenesinacetaminophen, dextromethorphan, doxylamine
Symptom(s) treatedchest congestionfever, cough, sleep congestion, minor aches and also pains, headache, sick throat, runny nose, sneezing
Usagethroughout the dayat night
Formsextended-release dental tablet*, oral granulesoral fluid capsule, dental solution
Risk of interactionsnoyes
Risk of significant side effectsnoyes

*There is additionally an extra-strength kind of this tablet, which consists of twice as lot of the energetic ingredient.

Forms and dosage

You have the right to use Mucinex transparent the day, but you generally use NyQuil in ~ night to help you sleep and let your body recover. The ingredient doxylamine in NyQuil likewise causes drowsiness to aid you acquire rest.

Mucinex and NyQuil Cold & Flu are only for civilization 12 years and older. However, NyQuil has actually other products that are especially made for kids ages 4 to 11 years.

The recommended dosage because that each drug varies according to the form. Monitor the encourage dosage on the package of whatever kind you choose. Girlfriend will have to ask your physician for the correct dosage the NyQuil to provide to children who space 4 come 11 year old.

Mucinex does not have the hazard of significant side effects. However, the complying with serious side impacts may be feasible with NyQuil:

vision problems, such together blurry visiondifficulty urinatingallergic reaction, with symptoms together as:red, skin or blistering skinrashhivesitchingswelling the the face, throat, tongue, lips, eyes, hands, or reduced legsdifficulty breathing or swallowing

If you have actually serious side effects, you should stop making use of the drug and also call her doctor.


Drug interactions deserve to increase or to decrease the impact of the various other medications. Interactions can additionally increase your threat of side effects. There space no known significant interactions with guaifenesin, the active ingredient in Mucinex. However, all three energetic ingredients the NyQuil connect with other drugs.

Acetaminophen can connect with:

warfarinisoniazidcarbamazepine (Tegretol)phenobarbitalphenytoin (Dilantin)phenothiazines

Dextromethorphan can communicate with:

isocarboxazidphenelzine (Nardil)selegilinetranylcypromine (Parnate)

Doxylamine can communicate with:

isocarboxazidphenelzine selegilinetranylcyprominelinezolidopioids such as fentanyl, hydrocodone, methadone, and morphine

You shouldn’t usage Mucinex or NyQuil come treat a irreversible cough. Utilizing too much can cause harmful effects. You additionally shouldn’t usage these assets to treat symptom of any type of medical problem you have actually without talking to your medical professional first.

Other conditions

Other problems you may have actually can impact how NyQuil works for you. In some conditions, this drug have the right to be harmful. Ask a doctor prior to using NyQuil if friend have:

liver diseaseglaucomaurinating because of enlarged prostate gland


Don’t use Mucinex or NyQuil for longer than seven days. If her symptoms no relieved ~ a week, contact your doctor and also stop using these drugs.

NyQuil contains acetaminophen, which can cause far-ranging liver damages if friend overuse it. Taking more than four doses that NyQuil in 24 hrs can reason severe liver damage. Many over-the-counter drugs additionally contain acetaminophen. If you take it NyQuil, make sure you don’t take it with other drugs that contain acetaminophen. This will assist make sure you nothing accidentally usage too lot of the drug.

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Mucinex and also NyQuil space both products that relax symptoms the the usual cold or flu. The symptom they treat are different. You deserve to take Mucinex and also NyQuil together safely if you follow the encourage dosage for each drug. However, taking Mucinex in ~ night v NyQuil might actually store you indigenous falling asleep. Mucinex will certainly loosen your mucus, which can reason you come wake approximately cough.

Deciding in between the two might simply mean choosing the medicine that treats the symptom that space bothering you the most. The course, you have to never take any drug if you’re no sure exactly how to use it or if it’s appropriate for you. Constantly talk to your medical professional if you have questions.